| Foreword: The Top-Secret Truth About Captain Underpants | p. 9 |
| 1. | George and Harold | p. 13 |
| 2. | All Hail New Swissland | p. 17 |
| 3. | The Field Trip | p. 25 |
| 4. | Left Behind | p. 31 |
| 5. | The Fun Begins | p. 37 |
| 6. | Bye Bye, Mr. Fyde | p. 45 |
| 7. | Here, Oh Here | p. 49 |
| 8. | The Sweetness and Innocence of Children | p. 53 |
| 9. | The Gerbil Jogger 2000 | p. 59 |
| 10. | Just One More Thing | p. 63 |
| 11. | Captain Underpants and the Pied Pooper of Piqua | p. 65 |
| 12. | Professor P. Goes Cra-Z | p. 73 |
| 13. | Honey, I Shrunk the School | p. 75 |
| 14. | The Perilous Plot | p. 81 |
| 15. | The Name Change-O-Chart 2000 | p. 85 |
| 16. | Fluffy and Cheeseball | p. 93 |
| 17. | Captain Underpants to the Rescue | p. 97 |
| 18. | Are You There, God? It's Us, Fluffy and Cheeseball | p. 101 |
| 19. | The Flight of the Goofy Glider | p. 105 |
| 20. | X-tra, X-tra, X-tra, X-tra, X-tra, X-tra, X-tra, X-tra, X-tra Large Underpants | p. 113 |
| 21. | The Incredibly Graphic Violence Chapter (in Flip-O-Rama) | p. 119 |
| 22. | The Twenty-Second Chapter | p. 139 |
| 23. | To Make a Long Story Short | p. 143 |
| 24. | The Chapter Before the Last Chapter | p. 144 |
| 25. | The Chapter After the Chapter Before the Last Chapter | p. 149 |